I don’t, but I figured out what is going on. The issue is with f.lux, an app that automates a night-light like feature. They also had issues with other virtual/secondary display apps like displaylink. It looks like that in that case it is an issue with display link, check this example: https://www.displaylink.org/forum/showthread.php?t=68201
Do you think that is an issue with spacedesk or with f.lux? Can I help in any way?