Nobody has ever reported such a problem. If it continues after spacedesk is uninstalled, then it is very unlikely that it is related to spacedesk. Still we would like to troubleshoot as far as possible. First question: Did you already try if rebooting the machine fixes the flickering? Did you already try if updating your graphics drivers fixes the flickering? To help us understand your environment, please run dxdiag.exe (just type in “dxdiag”), click the button “Save all information” and send us the resulting text file. Could you also send us a video of your flickering. This might give us an idea of what kind of problem you are facing.